Over-simplification inherent to meme images aside for another day, that NPC meme has always felt a little unsavoury to me compared to almost every other common political meme, lately. The fact that they continue to surface even in the face of the Ukraine invasion tells me I was probably right to suspect it ran deeper than being 'just a joke.'
Dehumanising your opponent, if you buy into it, means that they get permanently 'othered' and you will never bother attempting to understand how their views came about. Likewise, you are less likely to self-criticise and improve your own understanding if all criticisms to it come from places you deem 'other' and therefore automatically invalid.
Think about it - there's an extremely good reason that one of Putin's headline messages to Russia going into the invasion, was to focus on branding the Ukraine as neo-nazis.
Most likely, it's going to become more important than ever before to be self-critical and to evaluate everything, and everyone you read, as to how they have formed their conclusions. Reality is messy and complicated, and your understanding of the world and the people in it needs to be just as messy and complicated, otherwise you're simplifying towards error.