On consumer devices, not any more IMHO - Windows Defender is pretty decent ,MFA and education are more important along with a tested backup of anything you don't want to loose.
On a corporate machine, yes, but its a small part of a bigger picture these days.
MFA is the single most important thing, followed by education, and then enforcement etc via Azure CA or Intune or GroupPolicy or whatever you've doing, ideally you really want your A/V solution to tie in with the rest of the stack - we use Defender ATP as it integrates with Intune.
Back in the pre-covid more on-prem days we were looking at InterceptX as it ties in with the Sophos hardware we have at the perimeter, all of which looks a bit old fashioned a year later!
But if you do nothing else get MFA enabled on anything you care about.